The trinucleotide repeat sequence d(GTC)15adopts ahairpin conformation

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The trinucleotide repeat sequence d(GTC)15 adopts a hairpin conformation.

The structure of a single-stranded (ss) oligonucleotide containing (GTC)15 [ss(GTC)15] was examined. As a control, parallel studies were performed with ss(CTG)15, an oligonucleotide that forms a hairpin. Electrophoretic mobility, KMnO4 oxidation and P1 nuclease studies demonstrate that, similar to ss(CTG)15, ss(GTC)15 forms a hairpin containing base paired and/or stacked thymines in the stem. E...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 1995

ISSN: 0305-1048,1362-4962

DOI: 10.1093/nar/23.14.2706